PI

Chuang Liu, PhD

2026/01                       Assistant Professor

                                           Department of Pharmacy and Pharmaceutical Sciences (Faculty of Science)

                                           Department of Physiology (Yong Loo Lin School of Medicine)

2021/06 – 2025/12      Research Fellow / Faculty Research Scientist

                                           Department of Neurosurgery, Center for Stem Cell and Translational Immunotherapy,

                                           Department of Anaesthesiology, Center for Nanomedicine,

                                           Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

2016/09 – 2021/06     Ph.D. in Materials Physics and Chemistry

                                           Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences

                                           University of Chinese Academy of Sciences, China.

2020/01 – 2021/06     Visiting Ph.D. Student

                                           Department of Anaesthesiology, Center for Nanomedicine,

                                           Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

Dr. Liu's research interests lie in immunotherapy, particularly for cancer, using modalities such as mRNA, gene-engineered cells and bacteria, and oncolytic viruses. He has published 22 first and co-corresponding author papers in top-tier journals, including Nature Nanotechnology, Nature Reviews Cancer, Nature Protocols, Nature Materials, Nature Reviews Chemistry (2), Nature Reviews Endocrinology, Nature Reviews Bioengineering, Nature Reviews Materials, Advanced Materials, Chemical Society Reviews, Nano Letters, and Angewandte Chemie, etc.

Departmental Page: https://pharmacy.nus.edu.sg/  https://medicine.nus.edu.sg/phys/

Research Fellows

Jing ZHANG

Hello, I am Zhang Jing. In 2025, I received a Ph.D. in Pharmaceutics from Shandong University. Before joining Chuang lab, I was mainly engaged in nucleic acid drug delivery, biochemistry, biomolecular and biomedical engineering, cancer biology, cancer immunology and neurodegenerative diseases of the central nervous system. I currently focus on the research and development of intelligent design and precision delivery strategies for RNA nanomedicine. At the same time, I am also very interested in the application of artificial intelligence in drug delivery systems.

 

I am a skilled event host with a knack for engaging audiences and ensuring the seamless flow of occasions. In my leisure time, I enjoy playing the guitar, swimming, and practicing yoga.

 

Publications:

  1. Jing Zhang#, Chen Chen#, Anning Li, Weiqiang Jing, Peng Sun, Xueyang Huang, Yingchao Liu, Shengchang Zhang, Wei Du, Rui Zhang, Ying Liu, Aihua Gong, Jibiao Wu, Xinyi Jiang*. Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection. Nature Nanotechnology, 2021 May;16(5):538-548.
  2. Yan Wang#, Jing Zhang#, Ying Liu#, Xiao Yue, Kun Han, Zhichao Kong, Yuanmin Dong, Zhenmei Yang, Zhipeng Fu, Chunwei Tang, Chongdeng Shi, Xiaotian Zhao, Maosen Han, Zhibin Wang, Yulin Zhang, Chen Chen, Anning Li, Peng Sun, Danqing Zhu, Kun Zhao, Xinyi Jiang*. Realveolarization with inhalable mucus-­penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice. Science Advances, 2024 Jun 14;10(24):eado4791.
  3. Chongdeng Shi#, Jing Zhang#, Huijun Wang, Chen Chen, Maosen Han, Lin Gao, Chunwei Tang, Peng Sun, Xiaotian Zhao, Feiyue Guo, Zhaozhong Wang, Mohnad Abdalla, Zhenmei Yang, Ying Liu, Anning Li, Cai Zhang*, Xinyi Jiang*. Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice. Advanced Materials, 2023 Mar;35(11):e2210262.
  4. Yuanmin Dong#, Jing Zhang#, Yan Wang, Yulin Zhang, Daniella Rappaport, Zhenmei Yang, Maosen Han, Ying Liu, Zhipeng Fu, Xiaotian Zhao, Chunwei Tang, Chongdeng Shi, Daizhou Zhang, Dawei Li, Shilei Ni, Anning Li, Jiwei Cui, Tao Li, Peng Sun, Ofra Benny, Cai Zhang*, Kun Zhao*, Chen Chen*, Xinyi Jiang*. Intracavitary Spraying of Nanoregulator-Encased Hydrogel Modulates Cholesterol Metabolism of Glioma-Supportive Macrophage for Postoperative Glioblastoma Immunotherapy. Advanced Materials, 2024 Mar;36(13):e2311109.
  5. Dawang Zhao#, Jing Zhang#, Chen Chen#, Weiyi Sun, Ying Liu, Maosen Han, Yulin Zhang, Zhipeng Fu, Chongdeng Shi, Xiaotian Zhao, Zhenmei Yang, Chunwei Tang, Kun Zhao, Danqing Zhu, Yuankai Zhang*, Lei Cheng*, Xinyi Jiang*. Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration. Advanced Materials, 2025 Feb;37(7):e2409979.
  6. Qiongqiong Gao#, Jing Zhang#, Chen Chen, Menglin Chen, Peng Sun, Wei Du, Shengchang Zhang, Ying Liu, Rui Zhang, Mei Bai, Changchun Fan, Jibiao Wu, Tongyi Men*, Xinyi Jiang*. In situ Mannosylated Nanotrinity-mediated Macrophages Remodeling Combats Candida albicans Infection. ACS NANO, 2020 Apr 28;14(4):3980-3990.

Qin WANG

Hi, I am Qin Wang. I received my PhD in Cell Biology from the University of Science and Technology of China (USTC) in 2022, and subsequently conducted postdoctoral training at both USTC and the Macau University of Science and Technology. Before joining the Chuang Lab, my research focused on using intravital microscopy to uncover the mechanisms governing nanomedicine transport across vascular, immune, and epithelial barriers, and to guide the rational design of delivery systems. In Chuang Liu’s lab, I will continue to develop mRNA-based nanomedicines and mechanistically study their interactions with the biological interface to enable accurate and effective therapeutic delivery.

 

Outside the lab, I enjoy traveling and photography.

 

Publications:

1. Q. Wang#, Z. Chen#, G. Zhang#, J. Yang, R. Hu, T. Yao, Y. Shen, C. Zeng, S. Zhang, W. Jiang*, S. Zhu*, Y. C. Wang*. Science, 2026, in press.

2. Q. Wang#, Q. Liang#, J. Dou, H. Zhou, C. Zeng, H. Pan, Y. Shen, Q. Li, Y. Liu, D. T. Leong*, W. Jiang*, Y. C. Wang*. Breaking Through the Basement Membrane Barrier to Improve Nanotherapeutic Delivery to Tumors. Nature Nanotechnology, 2024, 19, 95–105.

3. W. Jiang#, Z. Guo#, Q. Wang#, *, Z. Chen, W. Dong, Q. Liang, Y. Hao, H. Pan, C. Zeng, H. Liu* and Y.C. Wang*. Enhanced Nanoparticle Delivery Across Vascular Basement Membranes of Tumours Using Nitric Oxide. Nature Biomedical Engineering, 2025, 9, 1486–1501.

4. G. Zhang#, Q. Wang#, W. Tao#, W. Jiang, E. Elinav, Y. C. Wang*, S. Zhu*. Glucosylated Nanoparticles for the Oral Delivery of Antibiotics to the Proximal Small Intestine Protect Mice from Gut Dysbiosis. Nature Biomedical Engineering, 2022,6, 867–881. 

5. M. l. Setyawati#, *, Q. Wang#, N. Ni, J. K. Tee, K. Ariga, P. C. Ke, H. K. Ho, Y. C. Wang*, D. T. Leong*. Engineering Tumoral Vascular Leakiness with Gold Nanoparticles. Nature Communications, 2023, 14, 4269.

6. M. Luo#, Q. Wang#, G. Zhao#, W. Jiang, C. Zeng, Q. Zhang, R. Yang, W. Dong, Y. Zhao, G. Zhang, J. Jiang, Y. C. Wang*, Q. Zhu*. Solid-State Atomic Hydrogen as a Broad-Spectrum RONS Scavenger for Accelerated Diabetic Wound Healing. National Science Review, 2024, 11, nwad269.

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Postgraduate Students

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Undergraduate Students

Jagger Wong

Hello! I am Jagger Wong. I am a Life Sciences major at NUS doing an FYP (Final-Year-Project) with the Chuang lab. My interests generally lie in immunotherapy and immunology.

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Lab Moments

2025

Alumni

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