Laboratory for Gene 🧬 Medicine

We are a multidisciplinary research team dedicated to unlocking the power of genetic science to develop the next generation of therapies.

By bridging fundamental discovery with translational innovation, we strive to make curative genetic medicines a reality.

Research Interest

Gene medicine

Designing and optimizing next-generation gene (e.g. mRNA) therapeutics.

Cell medicine

Leveraging gene-engineered cells as therapeutic candidates.

Delivery platforms

Developing novel gene delivery platforms to enhance therapeutic efficacy.

Selected Publications (*corresponding author)

• Chuang Liu, Xiangang Huang, Kok-Siong Chen, Sihan Xiong, Alexey V Yaremenko, Xueyan Zhen, Xinru You, Filippo Rossignoli, Yi Tang, Seyoung Koo, Wei Chen, Na Kong, Tian Xie, Khalid Shah, Wei Tao*. Systemic reprogramming of tumour immunity via IL-10-mRNA nanoparticles. Nature Nanotechnology (2025), 20, 1526–1538.
• Chuang Liu#, Qiangqiang Shi#, Xiangang Huang, Seyoung Koo, Na Kong*, Wei Tao*. mRNA-based cancer therapeutics. Nature Reviews Cancer (2023), 23, 526–543.
• Chuang Liu#, Alexey V. Yaremenko#, Xiaolong Li#, Xinru You, Xiaoyu Zhu, Nuo Liu, Wei Chen, Na Kong, Tian Xie, Gaurav D. Gaiha*, Robert Langer, and Wei Tao*. mRNA technology for the prevention and treatment of HIV-1 infection. Nature Reviews Bioengineering (2026), 4, 435–453.
• Chuang Liu*. mRNA-based enzyme replacement for propionic acidaemia. Nature Reviews Endocrinology (2025), 21, 526.
• Chuang Liu, Khalid Shah*. Taming CAR T cell therapy toxicity. Nature Materials (2023), 22, 1444–1445.
• Sihan Xiong, Chuang Liu*. Breaking the PEG barrier to boost mRNA-LNP therapeutics. Nature Reviews Materials (2025), 10, 799–800.
• Sihan Xiong, Chuang Liu*. Core mission: mRNA endosomal escape. Nature Reviews Chemistry (2025), 9, 433.
• Sihan Xiong, Khalid Shah*, Chuang Liu*. A zwitterionic twist. Nature Reviews Chemistry (2024), 8, 721.
• Xiangang Huang#, Chuang Liu#, Na Kong, Yufen Xiao, Arif Yurdagul, Ira Tabas, Wei Tao*. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols (2022), 17, 748–780.

Interested in our lab? 

Please join us!

We are seeking highly motivated and responsible individuals to join our lab.

Lab address: S9 #06-07, 4 Science Drive 2, Singapore 117544

Email: chuangliu@nus.edu.sg